SCI收录论文（近五年）

1. Li J, Xie M, Wang X, Ouyang X, Wan Y, Dong G, Yang Z, Yang J, Yue J*. Sex hormones regulate cerebral drug metabolism via brain miRNAs: down-regulation of brain CYP2D by androgens reduces the analgesic effects of tramadol. Br J Pharmacol. 2015; 172: 4639-4654.

2. Luo HW#, Li J#, Cao H, Tan Y, Magdalou J, Chen LB*, Wang H*. Prenatal caffeine exposure induces a poor quality of articular cartilage in male adult offspring rats via cholesterol accumulation in cartilage. Scientific Report 2015; 5:17746.

3. He Z#, Li J#, Luo HW, Zhang L, Ma L, Chen LB, Wang H*. Sex-dependent increase in susceptibility to metabolic syndrome in adult offspring after prenatal ethanol exposure with post-weaning high-fat diet. Scientific Report 2015; 5:17679.

4. Ni QB, Tan Y, Zhang XR, Luo HW, Deng Y, Chen LB, Wang H*. Prenatal ethanol exposure increases osteoarthritis susceptibility in female rat offspring by programming a low-functioning IGF-1 signaling pathway. Scientific Report 2015;5:14711

5. Wu YM, Luo HW, Kou H, Wen YX, Shen L, Pei LG, Zhou J, Zhang YZ, Wang H*. Prenatal caffeine exposure induced a lower level of fetal blood leptin mainly via placental mechanism. Toxicol Appl Pharmacol. 2015;289(1):109-16.

6. Ni QB, Wang LL, Wu Y, Shen L, Qin J, Liu YS, Magdalou J, Chen LB*, Wang H*. Prenatal ethanol exposure induces osteoarthritis-like phenotype in female adult offspring rats with post-weaning high-fat diet and its intrauterine programming mechanisms of cholesterol metabolism. Toxicol Lett 2015:238:117–25.

7. Huang HG, He Z, Zhu CY, Liu L, Kou H, Shen L, Wang H*. Prenatal ethanol exposure-induced adrenal developmental abnormality of male offspring rats and its possible intrauterine programming mechanisms. Toxicol Appl Pharmacol 2015;288:84–94

8. Ao Y, Sun ZX, Hu SS, Zuo N, Li B, Yang SL, Xia LP, Wu Y, Wang LL, He Z, Wang H*. Low functional programming of renal AT2R mediates the developmental origin of glomerulosclerosis in adult offspring induced by prenatal caffeine exposure. Toxicol Appl Pharmacol 2015;287:128-138

9. Sun ZX, Hu SS, Zuo N, Yang SL, He Z, Ao Y*, Wang H*. Angiotensin II receptor-mediated glomerularsclerosis in male adult offspring induced by prenatal nicotine exposure. Toxicol Res, 2015, 4, 1045-58.

10. Lu J#, Wen YX#, Zhang L, Zhang C, Zhong WH, Zhang L, Yu Y, Chen LB, Xu D*, Wang H*. Prenatal ethanol exposure induces an intrauterine programming of enhanced sensitivity of the hypothalamic-pituitary-adrenal axis in female offspring rats fed with post-weaning high-fat diet. Toxicol Res 2015;4:1238-49.

11. Li J#, Luo H W#, He Z, Zhang L, Guo Y, Ma L, Magdalou J, Chen LB, Wang H*. Gender-specific increase in susceptibility to metabolic syndrome of offspring rats after prenatal caffeine exposure with post-weaning high-fat diet. Toxicol Appl Pharmacol, 2015; 284(3):345-53

12. Xu D#, Bai J#, Zhang L, Shen L, Wang LL, Liu ZF, Xia LP, Wang H*. Prenatal nicotine exposure-induced intrauterine programming alteration increases the susceptibility of high-fat diet-induced non-alcoholic simple fatty liver in female adult offspring rats. Toxicol Res 2015; 4(1):112-20.

13. Wu DM#, He Z#, Ma LP, Wang LL, Ping J*, Wang H. Increased DNA methylation of scavenger receptor class B type I contributes to inhibitory effects of prenatal caffeine ingestion on cholesterol uptake and steroidogenesis in fetal adrenals. Toxicol Appl Pharmacol. 2015;285(2):89-97.

14. Zhang FR, Yu XM, He CY, Ouyang XF, Wu JH, Li J, Zhang JJ, Duan XJ, Wan Y, Yue J*. Effects of sexually dimorphic growth hormone secretory patterns on arachidonic acid metabolizing enzymes in rodent heart. Toxicol Appl Pharmacol. 2015; 289(3):495-506

15. Qin T, Wang C, Chen X, Duan C, Zhang X, Zhang J, Chai H, Tang T, Chen H, Yue J, Li Y, Yang J*. Dopamine induces growth inhibition and vascular normalization through reprogramming M2-polarized macrophages in rat C6 glioma. Toxicol Appl Pharmacol. 2015, 15;286(2):112-23.

16. Xi J, Yue J, Yang Z*. Expression profiles of retinoic acid synthetases ALDH1As and metabolic enzymes CYP26s in adult and embryonic zebrafish (Danio rerio). Genet Mol Res. 2015; 14(2), 3948 – 3956.

17. Xie XF*, Zou GL, Li CH. Antitumor and immunomodulatory activities of a water-soluble polysaccharide from Chaenomeles speciosa. Carbohydr Polym, 2015; 132: 323-329.

18. Xie XF*, Wang JW, Zhang HP. Characterization and antitumor activities of a water-soluble polysaccharide from Ampelopsis megalophylla. Carbohydr Polym, 2015; 129: 55-61.

19. Wen YX, Li J, Wang LL, Tie K, Magdalou J, Wang H*, Chen LB*. UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis. Arthritis Research & Therapy 2014; 16(6):484.

20. Zhang C^#, Xu D^#, Luo HW, Lu J, Liu L, Ping J, Wang H*. Prenatal xenobiotic exposure and intrauterine hypothalamus-pituitary-adrenal axis programming alteration. Toxicology. 2014;325C:74-84.

21. Feng JH*^#, Yan YE, Liang G, Liu YS, Li XJ, Zhang B J, Chen LB, Yu H, He XH, Wang H*. Maternal and fetal metabonomic alterations in prenatal nicotine exposure-induced rat intrauterine growth retardation. Mol Cell Endocrinol. Accepted. Mol Cell Endocrinol 2014;394(1-2):59-69.

22. Ping J^#, Wang JF^#, Liu L, Yan YE, Liu F, Lei YY, Wang H*. Prenatal caffeine ingestion induces aberrant DNA methylation andhistone acetylation of steroidogenic factor 1 and inhibits fetaladrenal steroidogenesis. Toxicology 2014;321:53-61.

23. Yan YE^#, Liu L^#, Wang JF, Liu F, Li XH, Qin HQ, Wang H*. Prenatal nicotinic exposure suppresses fetal adrenal steroidogenesis via steroidogenic factor 1 (SF-1) deacetylation. Toxicol Appl Pharmacol., 2014;277:231-41.

24. Xia LP^#, Shen L^#, Kou H, Zhang BJ, Zhang L, Wu Y, Li XJ, Xiong J, Yu Y, Wang H*. Prenatal ethanol exposure enhance the susceptibility to metabolic syndrome in offspring rats by HPA axis-associated neuroendocrine metabolic programming. Toxicol lett. 2014;226:98-105.

25. Kou H^#, Liu Y^#, Liang G, Huang J, Hu J, Yan YE, Li X, Yu H, He X, Zhang B, Zhang Y, Feng J, Wang H*. Maternal glucocorticoid elevation and associated blood metabonome changes might be involved in metabolic programming of intrauterine growth retardation in rats exposed to caffeine prenatally. Toxicol Appl Pharmacol. 2014;275(2):79-87.

26. Luo H, Deng Z, Liu L, Shen L, Kou H, He Z, Ping J, Xu D, Ma L, Chen L, Wang H*. Prenatal caffeine ingestion induces transgenerational neuroendocrine metabolic programming alteration in second generation. Toxicol Appl Pharmacol. 2014;274(3)383-92.

27. Shen L, Liu ZF, Gong J, Zhang L, Wang LL, Magdalou J, Chen LB, Wang H*. Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats. Toxicol Appl Pharmacol, 2014;274(2)263-73.

28. Wang LL^#, Shen L^#, Ping J, Zhang L, Liu ZF, Wu Y, Liu YS, Huang HG, Chen LB, Wang H*. Intrauterine metabolic programming alteration increased susceptibility to non-alcoholic adult fatty liver disease in prenatal caffeine-exposed rat offspring. Toxicol lett. 2014;224(3):311-8.

29. L. Zhao, Y. Xu, H. Qin, S. Abe, T. Akasaka, T. Chano, F. Watari, T. Kimura, N. Komatsu*, X. Chen *. Platinum on Nanodiamond: A Promising Prodrug Conjugated with Stealth Polyglycerol, Targeting peptide, and Acid-Responsive Antitumor Drug. Adv Funct Mater. 2014; 24(34): 5348–5357.

30. L. Zhao, Y. Xu, S. Abe, T. Akasaka, T. Watari,  T. Kimura,  N. Komatsu,  X. Chen *. Polyglycerol-coated nanodiamond as a macrophage-evading platform for selective drug delivery in cancer cells. Biomaterials. 2014; 35(20): 5393–5406.

31. Guo Y^#, Ma Z^#, Kou H, Sun R, Yang H, Smith CV, Zheng J*, Wang H*. Synergistic effects of pyrrolizidine alkaloids and lipopolysaccharide on preterm delivery and intrauterine fetal death in mice. Toxicol Lett. 2013;221:212-8

32. Xu D^#, Xia LP^#, Shen L, Lei YY, Liu L, Zhang L, Magdalou J, Wang H*. Prenatal nicotine exposure enhances the susceptibility to metabolic syndrome in adult offspring rats fed high-fat diet viaalteration of HPA axis-associated neuroendocrine metabolic programming. Acta Pharmacol Sin. 2013;34:1526-34.

33. Zhang L^#, Xu D^#, Zhang B, Liu Y, Chu F, Guo Y, Gong J, Zheng X, Chen L, Wang H*. Prenatal food restriction induces a hypothalamic-pituitary-adrenocortical axis-associated neuroendocrine metabolic programmed alteration in adult offspring rats. Arch Med Res 2013;44:335-45.

34. Shang YZ, Zhang H, Cheng JJ, Miao H. Liu YP, Cao K, Miao H, Wang H*. Falvonoid from Scutellaria baicalensis Georgi are effective to treat cerebral ischemia/reperfusion. Neural Regeneration Research 2013;8:514-22.

35. Li Y^#, Zhao H, Wang Y, Zheng H, Yu W, Chai H, Zhang J, Falck JR, Guo AM, Yue J, Peng R, Yang J*. Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. Toxicol Appl Pharmacol. 2013;272:37-48.

36. Deng Y, Cao H, Cu F, Xu D, Lei YY, Tan Y, Magdalou J, Wang H, Chen LB*. Nicotine-induced retardation of chondrogenesis through down-regulation of IGF-1 signaling pathway to inhibit matrix synthesis of growth plate chondrocytes in fetal rats. Toxicol Appl Pharmacol 2013;269:25-33.

37. Luo GC, Kong XC, Lu LN, Xu XH, Wang H, Ma XS*. Glucagon-like peptide 1 potentiates glucotoxicity-diminished insulin secretion via stimulation of cAMP-PKA signaling in INS-1E cells and mouse islets. International J Biochem Cell Biol 2013;45:483-90.

38. Cheng Y, X. Chen *, Song W, Kong Z, Li P, Liu Y. Contribution of silver ions to the inhibition of infectivity of Schistosoma japonicum cercariae caused by silver nanoparticles. Parasitology. 2013; 140(5):617-625.

39. Xiong J, Guo Y, Li LY, Hu H, Qu XL, Sun XZ, Liu SH, Wang H*. A Herbal Composition of Semen Hoveniae, Radix Puerariae, and Fructus Schisandrae Shows Potent Protective Effects on Acute Alcoholic Intoxication in Rodent Models. Evidence-Based Complementary and Alternative Medicine. 2012;2012:638197

40. Qin J, Shang L, Ping AS, Li XJ, Yu H, Magdalou J, Chen LB, Wang H*. TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1beta-induced rat osteoarthritis chondrocytes in vitro. Arthritis Research & Therapy. 2012;14(6):R242

41. Xu D, Wu Y, Liu F, Liu YS, Shen L, Lei YY, Liu J, Ping J, Qin J, Zhang C, Chen LB, Magdalou J, Wang H*. A hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic programmed alteration in offspring rats of IUGR induced by prenatal caffeine ingestion. Toxicol Appl Pharmacol. 2012;264(3):395-403

42. Liu YS, Xu D, Feng JH, Kou H, Liang G, Yu H, He XH, Zhang BF, Chen LB, Magdaloue J, Wang H*. Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways. Toxicol Appl Pharmacol. 2012;262:205-16

43. Xu D, Zhang BJ, Liang G, Ping J, Kou H, Li XJ, Xiong J, Chen LB, Magdalou J, Wang H*. Caffeine-induced Activated glucocorticoid metabolism in hippocampus causes hypothalamic-pituitary-adrenal axis inhibition in fetal rats. Plos One. 2012;7(9):e44497  

44. Guo Y*, Zhu LR, Lu G, Wang H, Hong JY. Selective Expression of CYP2A13 in Human Pancreatic Islet Cells. Drug Metab Dispo 2012;10:1878-82

45. Xu D, Liang G, Yan YE, He WW, Liu YS, Chen LB, Magdalou J, Wang H*. Nicotine-induced over-exposure to maternal glucocorticoid and activated glucocorticoid metabolism causes hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic alterations in fetal rats.Toxicol Lett. 2012;209:282-90

46. Liu L, Liu F, Kou H, Zhang BJ, Xu D, Chen B, Chen LB, Magdalou J, Wang H*. Prenatal nicotine exposure induced a hypothalamic-pituitary-adrenal axis-associated neuroendocrine metabolic programmed alteration in intrauterine growth retardation offspring rats. Toxicol Lett.2012 ;214:307-13

47. Ping J*, Lei Y, Liu L, Wang TT, Feng YH, Wang H*. Inheritable stimulatory effects of caffeine on steroidogenic acute regulatory protein expression and cortisol production in human adrenocortical cells. Chemico-Biological Interactions. 2012;195:68-75

48. Yu W, Chai HY, Li Y, Zhao HX, Xie XF, Zheng H, Wang CL, Wang X, Yang GF, Cai XJ, Falck JR, Yang J*. Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer. Toxicol Appl Pharm. 2012;264(1):73-83

49. Zhao HX, Li Y, Wang YZ, Zhang J, Ouyang XM, Peng RX, Yang J*. Antitumor and immunostimulatory activity of a polysaccharide–protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice. Food Chem Toxicol. 2012;50(8):2648-55

50. Zhong YY, Dong GC, Luo HG, Cao J, Wang C, Wu JY, Feng YQ, Yue J*. Induction of brain CYP2E1 by chronic ethanol treatment and related oxidative stress in hippocampus, cerebellum, and brainstem. Toxicology. 2012;302(2-3):275-84

51. Tian T, Li J, Wang MY, Xie XF, Li QX*. Protective effect of 20-hydroxyeicosatetraenoic acid (20-HETE) on adriamycin-induced toxicity of human renal tubular epithelial cell (HK-2).Euro J Pharmacol.2012;683:246-51

52. Huang J, Zhou S, Ping J, Pan XL, Liang G, Xu D, Kou H, Bao C, Wang H*. Role of p53-dependent placental apoptosis in the reproductive and developmental toxicities of caffeine in rodents. Clin Exp Pharmacol Physiol.      2012;39:357-63

53. Guo Y，Wu XQ,Zhang C,Liao ZX, Wu Y, Wang H*. Protective effect of sodium ferulate on acetaldehyde-treated precision-cut rat liver slices. J Med Food. 2012;15:557-62

54. Zhang XY, Zhou W, Xu H, Zhang YX, Yang J*, Duan GL. LC–ESI/MS Analysis of Levodopa and Methyldopa (IS) in Beagle Dog Pharmacokinetic Study after Oral Administration and Domperidone Given in Advance. J Chin Chem Soc. 2012;59:710-7

55. Zhang XY, Zhou W, Yang J*, Duan GL. Pharmacokinetic Study on Levodopa and Benserazide Hydrochloride Tablets in Beagle Dogs by HPLC-ESI-MS/MS. Lat Am J Pharm. 2012;31(9):1238-46

56. Song YJ，Li J，Xie XF，Wang H，Li QX*. Effects of amlodipine on TGF-b-induced Smad2, 4 expressions in adriamycin toxicity of rat mesangial cells. Archives of Toxicology. 2011，85：663-668.

57. Ping J, Gao AM, Qin HQ, Wei XN, Li XH, Bai J, Li RW, Ao Y, Wang H*. Indole-3-carbinol enhances the resolution of rat liver fibrosis and stimulates hepatic stellate cell apoptosis by blocking IKKa/IkB-a/NF-kB pathway. Pharmacol Exp Therap. 2011;339(2):694-703.

58. Wang TT, Chen M, Liu L, Cheng HY, Yan YE, Feng YH, Wang H*. Nicotine induced CpG methylation of Pax6 binding motif in StAR promoter reduces the gene expression and cortisol production. Toxicol Appl Pharmacol. 2011;257:328-37.

59. Ping J*, Lei Y, Liu L, Wang TT, Feng YH, Wang H*. Inheritable stimulatory effects of caffeine on steroidogenic acute regulatory protein expression and cortisol production in human Adrenocortical Cells. Chemico-Biological Interactions. 2012;195:68-75.

60. Yu W, Chen L, Yang YQ, Falck JR, Guo AM, Ying L, Yang J*. Cytochrome P450 omega-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer. Cancer Chemotherapy and Pharmacology. 2011; 68(3): 619-29.

61. Ping J, Li JT, Liao ZX, Shang L, Ao Y, Wang H*. Indole-3-carbinol inhibits hepatic stellate cells proliferation by blocking NADPH oxidase/reactive oxygen species/p38 MAPK pathway. Euro J Pharmacol. 2011;650(2-3):656-62.

62. Xue Y, Tie CR, Li J, Tian T, Li QX*. Ligustrazine inhibits lipopolysaccharide-induced proliferation by affecting P27, Bcl-2 expression in rat mesangial cells. European Journal of Pharmacology. 2011, 665: 8-12.

63. Liang G, Chen M, Pan XL, Zheng J, Wang H*. Ethanol-induced inhibition of fetal hypothalamic-pituitary-adrenal axis due to prenatal overexposure to maternal glucocorticoid in mice. Exp Toxic Pathol. 2011;63:607-11.

64. Xu D, Chen M, Pan XL, Xia LP, Wang H*.  Dexamethasone induces fetal developmental toxicity through affecting the placental glucocorticoid barrier and depressing fetal adrenal function. Environ Toxicol Pharmacol. 2011;32:356-63.

65. Li Y, Yan YY, Wang H*. Enhancement of placental antioxidative function and P-gp expression by sodium ferulate mediated its protective effect on rat IUGR induced by prenatal tobacco/alcohol exposure. Environ Toxicol Pharmacol. 2011;32:465-71.