姓名:彭芳芳
1.研究方向:任职与兼职:副教授
2.联系方式:
联系电话:027-68759795
Email:ffpeng66@hotmail.com
3.研究方向:
糖尿病肾病致肾小球硬化致病机理:主要研究高浓度葡萄糖以及高血压诱导糖尿病肾病致肾小球硬化的细胞信号传导机制。
4. 主要学习工作经历:
2002.09 – 2005.06 武汉大学生命科学学院遗传学、医学院内科学专业,博士
1997.09 – 2000.06 武汉大学医学院生物化学专业,硕士
1983.09 – 1987.06 华东理工大学生物化学专业,学士
5.教学工作:
从事本科生生物化学理论及实验,硕士生高级生物化学技术、分子生物学,博士生分子生物学、基因工程教学
6.科研工作:
2010.07-至今 主要从事高浓度葡萄糖以及高血压诱导糖尿病肾病致肾小球硬化的细胞信号传导机制的研究。主持国家自然科学基金资助项目:《PKCβ1介导MC细胞HG诱导的RhoA活化致糖尿病肾病的分子机制的研究》
2004.01-2010.07 加拿大McMaster大学肾病学系博士后,主要从事糖尿病肾病及高血压肾病细胞信号机制的研究,先后在《Diabetes》、《J Am Soc Nephrol》等国际著名期刊上发表多篇文章
1987.07-2003.12 武汉大学医学院生物化学与分子生物学系,主要从事心血管疾病信号传导机制的研究和神经细胞凋亡机制的研究。主持湖北省科技厅及湖北省卫生厅资助项目《早老性痴呆的分子病理研究和中药有效成分的筛选》,参与国家自然科学基金资助项目《Cdk5在早老性痴呆病理过程中的可能作用》。研究成果《神经细胞凋亡机制和乙酰胆碱酯酶抑制剂的抗凋亡作用的研究》于2003年获得湖北省自然科学奖三等奖,《脂蛋白致动脉粥样硬化形成机制的研究》获湖北省重大科学技术成果奖。
7.代表性论著:
1) Fangfang Peng, Dongcheng Wu, Bo Gao, AJ Ingram, Baifang Zhang, K Chorneyko, R Mckenzie, JC Krepinsky. .RhoA/Rho-kinase Contribute to the Pathogenesis of Diabetic Renal Disease. Diabetes. 2008 Jun; 57(6):1683-92. (IF:8.3)
2) Fangfang Peng, Dongcheng Wu, Alistair J. Ingram, Baifang Zhang, Joan C. Krepinsky. RhoA Activation in Mesangial Cells by Mechanical Strain Depends on Caveolae and Caveolin-1 Interaction. J Am Soc Nephrol. 2007 Jan; 18(1):189-98. (IF:7.5)
3) Fangfang Peng,Baifang, Zhang, Dongcheng Wu, Alistair Ingram; Bo Gao, Joan Krepinsky; TGF|*beta*|-Induced RhoA Activation and Fibronectin Production in Mesangial Cells Requires Caveolae.Am J Physiol Renal Physiol. 2008 Jul; 295(1):F153-64. (IF:6.8)
4) Fangfang Peng , Bai Zhang, AJ Ingram, Bo Gao, Ying Zhang, JC Krepinsky. Mechanical stretch-induced RhoA activation is mediated by the Rho GEF Vav2 in mesangial cells.Cell Signal. 2010 Jan; 22(1):34-40. (IF:4.50)
5) Dongcheng Wu,Fangfang Peng, Baifang Zhang, AJ Ingram, DJ Kelly, RE Gilbert, Bo Gao, JC Krepinsky. PKC-beta1 mediates glucose-induced Akt activation and TGF-beta1 upregulation in mesangial cells. J Am Soc Nephrol. 2009 Mar; 20(3):554-66. (IF:7.5)
6) Dongcheng Wu,Fangfang Peng, Baifang Zhang, AJ Ingram, DJ Kelly, RE Gilbert, Bo Gao, S Kumar JC Krepinsky.EGFR-PLCgamma1 signaling mediates high glucose-induced PKCbeta1-Akt activation and collagen I upregulation in mesangial cells.Am J Physiol Renal Physiol.2009 Sep;297(3):F822-34. (IF:6.8)
7) Baifang Zhang, Fangfang Peng, Dongcheng Wu, Alistair J. Ingram, Bo Gao, Joan C. Krepinsky. Caveolin-1 phosphorylation is required for stretch-induced EGFR and Akt activation in mesangial cells. Cell Signal. 2007 Aug; 19(8):1690-700. (IF:4.3)
8) Dongcheng Wu, Fangfang Peng, Baifang Zhang, Alistair. J. Ingram, Bo. Gao, Joan. C. Krepinsky Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells. Diabetologia, 2007 Sep; 50(9):2008-18. (IF:6.8)
9) Joan C. Krepinsky, Yanxia Li, Yanfei Chang, Lieqi Liu, Fangfang Peng, Dongcheng Wu, Damu Tang, James Scholey, Alistair J. Ingram. Akt Mediates Mechanical Strain-Induced Collagen Production by Mesangial Cells. J Am Soc Nephrol,16: 1661–1672, 2005. (IF:7.5)
10) Fangfang Peng, Baifang Zhang, Wen Zhang, Han Shen, Shaobo Wu, Dongcheng Wu. Involvement of cyclin dependent kinase 5 and its activator p35 in staurosporine-induced apoptosis of cortical neurons. Acta Pharmacol Sin, 2004, Sep; 25(9):1105-1111.
11) 彭芳芳主编《医学生物化学与分子生物学实验技术》武汉大学出版 (2003.09)
12) 彭芳芳参编《生物化学原理》高等教育出版社 (2003.09)