蔡国斌
蔡国斌

1、职称职务:副教授 硕士导师蔡国斌

2、学科专业:病原生物学 医学生物信息学

3、研究方向:寄生虫生殖生理与药物筛选

4、实验室位置:基础医学院3号楼5楼

5、联系电话:027-68759143(O)

6、Email:gbcai2011@whu.edu.cn

7、学习经历:

    2007年  武汉大学病原生物学专业  博士

    2003年  武汉大学病原生物学专业  硕士

    1994年  武汉大学生物学专业  学士

8、工作经历:

    2012/07-迄今  武汉大学,基础医学院病原生物学系,副教授

    2011/03~2012/06  Baylor College of Medicine(贝勒医学院,美国)  博士后

    2008/12~2011/02  武汉大学基础医学院病原生物学系  副教授

    2004/03~2006/10  Sungkyunkwan University(成均馆大学,韩国)  交流学者

    2000/01~2004/02  武汉大学基础医学院病原生物学系  讲师

    1994/07~1999/12  湖北医科大学基础医学院人体寄生虫学教研室  助教

9、主要科学研究领域:

    (1)寄生虫生殖、生理学研究:重点关注医学吸虫卵胚发育和虫卵形成过程中关键酶的分子特性和动力学研究,以及酶作用的分子机制研究。

    (2)小分子药物筛选及其抗病原体的机制研究:主要针对病原生物(如疟原虫、弓形虫、结核杆菌等)特有的类异戊二烯合成途径中关键酶的小分子抑制剂进行筛选;同时揭示小分子高效抑制关键酶的分子结构机制,以及其抗病原生物增殖作用的分子机制。

    主持湖北省卫生厅专项基金2项,国家自然科学基金子项目1项;参与国家自然科学基金项目4项、湖北省自然科学基金项目1项、省科技公关项目1项和省卫生厅基金重点项目1项等。鉴定成果1项,获湖北省科学技术类自然科学奖三等奖1项。发表学术论文近40篇,其中SCI源刊论文16篇,发表会议论文30余篇。

10、主要学术兼职:

    现担任北京热带医学与寄生虫学论坛学术委员会委员,和湖北省医学会热带病与寄生虫学分会委员会委员。现为中华预防医学会武汉分会及寄生虫学专业会员,中华预防医学会和中国动物学会会员,韩国寄生虫学会会员等。

10、教学情况:

    本科:临床医学、医学检验、预防医学等专业《人体寄生虫学》、《人体寄生虫学与检验》、《病原生物学》等课程的理论与实验教学;大学通识课《食源性寄生虫病》、《现代生活方式与寄生虫感染》课程教学;临床英语班《Pathogenic Biology》全英文理论和实验教学。

    研究生:《临床微生物学》、《医学生物信息学原理》、《病原生物学》、《病原生物学新进展》、《科学研究方法与规范》、《医学科技论文写作》、《医学文献信息检索》等课程理论教学。

11、主要代表性论著:

    1) Guobin Cai, Lisheng Deng, Jian Xue, Silvia N.J. Moreno, Boris Striepen, Yongcheng Song. Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5- phosphate reductoisomerase. Bioorganic & medicinal chemistry letters 2013, 23(7): 2158-2161.

    2) Xue Jian, Diao Jiasheng, Guobin Cai (Co-first), Lisheng Deng, Yongcheng Song. Antimalarial and Structural Studies of Pyridine-Containing Inhibitors of 1-Deoxyxylulose-5- phosphate Reductoisomerase. ACS Medicinal Chemistry Letters 2013, 4(2), 278-282.

    3) Young-An Bae, Guo-Bin Cai, Seon-Hee Kim, Woon-Mok Sohn, Yoon Kong. Expression pattern and substrate specificity of Clonorchis sinensis tyrosinases. International Journal for Parasitology 2013, 43(11): 891-900.

    4) Young-An Bae, Do-Whan Ahn, Eung-Goo Lee, Seon-Hee Kim, Guo-Bin Cai, Insug Kang, Woon-Mok Sohn, Yoon Kong. Differential Activation of Diverse Glutathione Transferases of Clonorchis sinensis in Response to the Host Bile and Oxidative Stressors. PLoS Negl. Trop. Dis. 2013, 7(5): e2211.

    5) Guobin Cai, Lisheng Deng, Bartlomiej G. Fryszczyn, Nicholas G. Brown, Zhen Liu, Hong Jiang, Timothy Palzkill, and Yongcheng Song. Thermodynamic Investigations of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase. ACS Medicinal Chemistry Letters 2012, 3, 496-500.

    6) Yuan He, Guobin Cai (Co-first), Yonghui Ni, Ying Li, Hongying Zong, Li He. siRNA-mediated knockdown of two tyrosinase genes from Schistosoma japonicum cultured in vitro. Experimental Parasitology 2012, 132: 394-402.

    7) Justin L. Anglin, Lisheng Deng, Yuan Yao, Guobin Cai, Zhen Liu, Hong Jiang, Gang Cheng, Pinhong Chen, Shuo Dong and Yongcheng Song. Synthesis and Structure-Activity Relationship Investigation of Adenosine-Containing Inhibitors of Histone Methyltransferase DOT1L. Journal of Medicinal Chemistry 2012, 55: 8066-8074.

    8) Baihua He, Guobin Cai (Co-first), Yonghui Ni, Ying Li, Hongying Zong, Li He. Characterization and expression of a novel cystatin gene from Schistosoma japonicum. Molecular and Cellular Probes 2011, 25: 186-193.

    9) Young-An Bae, Guo-Bin Cai, Seon-Hee Kim, Young-Gun Zo, Yoon Kong. Modular evolution of glutathione peroxidase genes in association with different biochemical properties of their encoded proteins in invertebrate animals. BMC Evolutionary Biology 2009, 6; 9: 72.

    10) S.-H. KIM, G.-B. CAI (Co-first), Y.-A. BAE, E.-G. LEE, Y.-S. LEE and Y. KONG. Two novel phospholipid hydroperoxide glutathione peroxidase genes of Paragonimus westermani induced by oxidative stress. Parasitology 2009, 136: 553-565.

    11) Guobin Cai, Youngan Bae, Ying Zhang, Yuan He, Mingsen Jiang, Li He. Expression and characterization of two tyrosinases from the trematode Schistosoma japonicum. Parasitology Research 2009, 104: 601-609.

    12) Guo-Bin Cai, Young-An Bae, Seon-Hee Kim, Woon-Mok Sohn, Yoon-Song Lee, Ming-Sen Jiang, Tong-Soo Kim, Yoon Kong. Vitellocyte-specific expression of phospholipid hydroperoxide glutathione peroxidases in Clonorchis sinensis. International Journal for Parasitology 2008, 38: 1613-1623.

    13) Guo-Bin Cai, Young-An Bae, Seon-Hee Kim, Byoung-Kuk Na, Tong-Soo Kim, Ming-Sen Jiang, Yoon Kong. A membrane-associated metalloprotease of Taenia solium metacestode structurally related to FACE-1/Ste24p protease family. International Journal for Parasitology 2006, 36: 925-935.

    14) Young-An Bae, Seon-Hee Kim, Guo-Bin Cai, Eung-Goo Lee, Tong-Soo Kim, Takeshi Agatsuma, Yoon Kong. Differential expression of Paragonimus westermani eggshell proteins during the developmental stages. International Journal for Parasitology 2007, 37: 295-305.

    15) Seon-Hee Kim, Joon-Yong Chung, Young-An Bae, Guo-Bin Cai, Byoung-Kuk Na, Nam-Joo Kim, Han-Shik Kwack, Tong-Soo Kim, Yoon Kong. Functional identification of protein inhibitor of neuronal nitric oxide synthase of Taenia solium metacestode. Molecular & Biochemical Parasitology 2007, 151: 41-51.

    16) He Li, Hu Chun-Song, Cai Guo-Bin, Zhang Qiu-Ping, Li Qun, Zhang Xiao-Lian, Huang Bao-Jun, Zhang Lin-Jie, Liu Jun-Yan, Jiang Ming-Sen, Tan Jing-Quan. Highly up-regulated CXCR3 expression on eosinophils in mice infected with Schistosoma japonicum. Immunology 2004, 111: 107-117.

    17) 章莹, 蔡国斌 (通讯作者), 何立, 等. 寄生性吸虫谷胱甘肽过氧化物酶生物信息学分析. 中国人兽共患病学报, 2010, 26 (4): 293-298.

    18) 蔡国斌, 董惠芬, 蒋明森. 医学吸虫抗氧化酶家族的研究进展. 中国寄生虫学与寄生虫病杂志. 2008, 26 (4): 313-317.