1、职称职务：教授 博导

2、学科专业：病原生物学

3、研究方向：病原生物感染引起的机体天然免疫调控机制的研究

4、实验室位置：基础医学院1号楼3楼海外实验室

5、联系电话：027-68759831（办公室）

6、邮箱：ruizhou@whu.edu.cn

7、学习经历：

    1996.09-2000.07 生物化学 本科 华中师范大学

    2000.09-2003.07 微生物学 硕士 华中师范大学

    2003.09-2006.07 病原生物学 博士 中国疾病预防控制中心病毒病预防控制所

8、工作经历：

    2007.05-2011.12病原生物学 博士后 Creighton University School of Medicine，USA

    2012.1-2012.05病原生物学 研究助理教授 Creighton University School of Medicine，USA

    2013.02-至今 教授 武汉大学基础医学院

9、目前主要科学研究领域和兴趣

    近年来主要从事病原生物感染引起的机体天然免疫调控机制的研究，侧重于非编码RNA在这一过程中起的作用。目前主持国家自然科学基金2项、教育部博士点基金1项及武汉大学人才项目1项。在SCI刊物及国内核心期刊上发表学术论文二十余篇。

10、教学情况

    2013年至今在武汉大学基础医学院寄生虫教研室从事教学科研工作。

11、近5年代表性论文

    1). Zhou R, Feng Y, Chen XM. Non-coding RNAs in epithelial immunity to Cryptosporidium infection. (2014) Parasitology. 141(10):1233-43.

    2). Zhou R, Gong AY, Chen D, Miller RE, Eischeid AN, Chen XM. Histone deacetylases and NF-?B signaling coordinate expression of CX3CL1 in epithelial cells in response to microbial challenge by suppressing miR-424 and miR-503. (2013) ?PLoS One. 8(5):e65153.

    3). Zhou R, Gong AY, Eischeid AN, Chen XM. miR-27b regulates RNA stability to coordinate TLR4/NF-kappaB-mediated epithelial anti-C. parvum defense by targeting KSRP. (2012) ?PLoS Pathogen. 8: e1002702.

    4). Zhao J, Gong AY, Zhou R, Liu J, Eischeid A, and Chen XM. ?Downregulation of PCAF by miR-181s provides feedback regulation to TNF-α-induced transactivation of pro-inflammatory genes in gastrointestinal epithelial cells. (2012) J Immunol. 188(33): 1266-1274.

    5). Zhou R, Li X, Hu G, Gong AY, Drescher KM, Chen XM. miR-16 Targets Transcriptional Corepressor SMRT and Modulates NF-kappaB-Regulated Transactivation of Interleukin-8 Gene. (2012) ?PLoS One. 7(1): e30772.

    6). Zhou R, O’Hara SP, Chen XM. MicroRNA regulation of innate immune responses in epithelial cells. (2011) Cell Mol Immunol. 8 (5):371-9.

    7). Hu G, Zhou R, Liu J, Gong AY, and Chen XM. MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling-4 in biliary epithelial cells in response to Cryptosporidium parvum infection. (2010) J Infect Dis. 202(1): 125-135.

    8). Zhou R, Hu G, Gong AY, and Chen XM. Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells. (2010) Nucleic Acids Research. 38(10): 3222-32.

    9). Li X, Liu J, Zhou R, Huang S, Huang S, Chen XM. Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation. （2010）Br J Haematol. 148(1): 69-79.

    10). Gong AY, Zhou R, Hu G, Liu J, Sosnowska D, Drescher KM, Dong H, Chen XM. Cryptosporidium parvum induces B7-H1 expression in cholangiocytes by down-regulating microRNA-513. (2010) J Infect Dis. 201(1): 160-169.

    11). Zhou R, Hu G, Liu J, Gong AY, Drescher KM, and Chen XM. NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses. (2009) PLoS Pathog. 5(12): e1000681.

    12). Hu G, Zhou R, Liu J, Gong AY, Eischeid AN, Dittman JW, and Chen XM. MicroRNA-98 and let-7 confer cholangiocyte expression of cytokine-inducible Src homology 2-containing protein in response to microbial challenge.（2009）J Immunol. 183(3): 1617-1624.

    13). Gong AY, Zhou R, Hu G, Li X, Splinter PL, O’Hara SP, LaRusso NF, Soukup GA, Dong H, and Chen XM. MicroRNA-513 regulates B7-H1 translation and is involved in IFN-gamma-induced B7-H1 expression in cholangiocytes.（2009）J Immunol. 182: 1325-33.