日前，2010年度国家杰出青年基金评审结果结束公示，正式公布，章晓联教授和化学与分子科学学院雷爱文教授获得资助。
国家杰出青年基金于1994年启动，其获得者多是全国各个专业学术领域的顶尖学者，其遴选资助人的重要指标之一为申请人的学术积累。该基金资助45周岁以下的优秀青年学者，申请者需在自然科学基础研究方面已取得国内外同行承认的突出的创新性成绩，或对本学科领域或相关学科领域的发展有重要的推动作用；在应用基础研究方面取得国内外同行承认的突出的创造性科技成果，或对国民经济与社会发展有较大影响。
章晓联1997年获香港科技大学生物化学博士学位，1997-2001在美国U. of Maryland at college Park作为博士后及研究专家，2004年期间赴日本福岛医科大学免疫学系作为访问学者。2001年作为引进人才回到武汉大学医学院免疫系工作至今。她长期从事胞内病原微生物的分子及感染免疫研究，在国际上率先发现伤寒杆菌病原毒力岛上的IV型纤毛基因操纵子和点特异重组酶基因，并阐明伤寒杆菌IV纤毛对人体细胞特异性致病机制，取得一系列国际领先水平成果。共发表核心期刊物以上论文60篇，文章被“Nature”等国际SCI杂志上文章引用112次。申请发明专利12项（已授权3项）。曾获第二届“中国青年女科学家提名奖”、“金绣球学术奖”、GTCbio Cytokines and Inflammation国际会议奖、中华医学奖、湖北杰出青年基金、武汉大学十大杰出青年等。
附：章晓联教授英文介绍
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Xiao-Lian Zhang |
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Chair of Immunology Department, Director of Hubei Province Key Laboratory of Allergy and Immunology, Professor of State Key Laboratory of Virology Wuhan University School of Medicine, Wuhan 430071, China |
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Research Field |
Infection and Immunology Glycoimmunity |
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keywords of my ongoing research work |
Hepatitis C Virus Mycobacterium Tuberculosis Lectin, pathogen surface glycans Immune escape Anti-infection immunity |
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Research Grants and Funding
National Outstanding Youth Foundation of China, Principle Investigator.
National Grand Program on Key Infectious Disease, Principle Investigator.
National 973 Program of China. Principle Investigator.
Prof. Xiao-LianZhang has published more than 100 professional research papers. She has applied for 42 patents and 25 patents were authorized.
Selected Publications (*: corresponding author)
1. Zhao Y, Ren Y, Zhang X, Zhao P, Tao W, Zhong J, Li Q, Zhang XL*. Ficolin-2 inhibits Hepatitis C Virus infection, whereas apolipoprotein E3 mediates viral immune escape. J Immunol.2014, 193(2):783-96 , cited by F1000Prime
2. Pan Q, Wang Q, Sun X, Xia X, Wu S, Luo F, Zhang XL*. Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeys. Mol Ther. 2014, 22(5):940-51.
3. Tang XL, Zhou YX, Wu SM, Pan Q, Xia B, Zhang XL*. CFP10 and ESAT6 aptamers as effective Mycobacterial antigen diagnostic reagents. J Infect. 2014, 69: 569-580.
4. Wu SM, Ai HW, Zhang DY, Han XQ, Pan Q, Luo FL, Zhang XL*. miR-141 targets ZEB2 to suppress HCC progression. Tumour Biol. 2014, 35(10):9993-7.
5. Luo F, Sun X, Wang Y, Wang Q, Wu Y, Pan Q, Fang C, Zhang XL*. Ficolin-2 defends against virulent Mycobacteria Tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. PloS One, 2013, 8 (9): e73859.
6. Yilan Hu, Fengling Luo, Junliang Fu, Tielong Chen, Shimin Wu, Yi-Dan Zhou, Xiao-Lian Zhang*. Early increased ficolin-2 concentrations are associated with severity of liver inflammation and efficacy of anti-viral therapy in chronic hepatitis C patients. Scand J Immunol 2013,77:144-150.
7. Pan Q, Chen H, Wang F , Jeza VT , Hou W, Zhao Y, Xiang T, Zhu Y, Endo Y, Fujita T, Zhang XL*L-ficolin binds to glycoproteins HA and NA and inhibits influenza A virus infection both in vitro and in vivo. J Innate Immun 2012. 4:312-24.
8. Chen HD, Zhou X, Yu G, Zhao YL, Ren Y, Zhou YD, Li Q, Zhang XL*. Knockdown of core 1 beta 1, 3-galactosyltransferase prolongs skin allograft survival with induction of galectin-1 secretion and suppression of CD8+T cells. J Clin Immunol 2012, 32:820-836.
9. Deng M, Feng S, Luo F, Wang S, Sun X, Zhou X*, Zhang XL*. Visual detection of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis using an asymmetrically split peroxidase DNAzyme. J. Clin. Microbiol. 2012.50: 3443-3450
10. Ma Y, Chen Hai-Dan, Wang Yubin, Wang Qilong, Li Yingying, Zhao Yinglan, Zhang Xiao-lian*. Interleukin 24 as a novel potential cytokine immunotherapy for the treatment of Mycobacterium tuberculosis infection. Microbes Infect. 2011, 13: 1099-1110.
11. Chen F, Zhao Y, Liu M, Li D, Wu H, Chen H, Zhu Y, Zhong J, Zhou Y, Qi Z, Zhang XL*. Functional Selection of Hepatitis C Virus Envelope E2 Binding Peptide Ligand Using Ribosome Display. Antimicrob Agents Chemother. 2010, 54: 3355-3364. cited by FACULTYof1000
12. Zhong B, Zhang L, Lei C, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL, Shu HB*.The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity 2009, 30(3):397-407.
13. Ma Y, Chen H, Wang Q, Luo F, Yan J, Zhang XL* IL-24 protects against Salmonella typhimurium infection by stimulating early neutrophil Th1 cytokine production that in turn activate CD8+ T cells. Eur J Immunol 2009, 39:3357-68.
14. Chen F, Hu Y, Li D, Chen H, and Zhang XL*. CS-SELEX generates high-affinity ssDNA aptamers as molecular probes for Hepatitis C Virus envelope glycoprotein E2. PloS One, 2009, 4 (12):e8142:1-11.
15. Li DQ, Li Y, Wu X, Li Q, Yu J, Gen J, Zhang XL*. Knockdown of Mgat5 inhibits breast cancer cell growth with activation of CD4+T cells and macrophages. J Immunol 2008, 80: 3158-3165.
Contact Information
Tel.: 86-27-68759986 (O);
E-mail: zhangxiaolian@whu.edu.cn; zhangXL65@sina.com