陈朗
陈朗

陈朗1、职称职务: 讲师

2、学科专业: 免疫学

3、研究方向:蛋白质晶体结构,天然免疫

4、联系电话: 18507161112

5Email langchen@whu.edu.cn

6、学习经历:

  1997-2002, Wuhan University, MD in Clinic Medication

  2003-2006, Wuhan University, B.S in Immunology

  2006-2009, Wuhan University, Ph.D in Immunology

7、主要工作经历与任职

  2010-2012, Postdoctoral Fellow, Department of pharmacology, University of Minnesota, MN, U.S.A.

  2013-present, Lecturer, Department of Immunology, Wuhan University School of Basic Medical Science.

8、目前主要科学研究领域和兴趣

  1)蛋白质结构及功能研究:关注病毒及其受体蛋白的结构及功能,免疫相关蛋白的结构与功能。

  2)天然免疫与肿瘤和感染性疾病的关系,抗肿瘤药物筛选。

9、教学情况:

  五年制,临川医学专业,护理专业,口腔专业《医学免疫学》

  七年制,临床医学专业,《医学免疫学》

  八年制,《损伤与反应》

10、近5年代表性论文

  1)Lang Chen, Yilun Lin, Guiqing Peng, Fang Li. Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc Natl Acad Sci U S A. 2012.109(44):17966-71.

  2)Lang Chen, Fang Li. Structural analysis of the evolutionary origins of influenza virus hemagglutinin and other viral lectins Journal of Virology, 2013. 87, 4118-4120.

  3)Guiqing Peng, Liqing Xu, Yi-Lun Lin, Lang Chen, Joseph Pasquarella, Kathryn Holmes, Fang Li.. Crystal structure of bovine coronavirus spike protein lectin domain. J Biol Chem. 2012 Oct 22.

  4)Li L, Wang L, Xiao R, Zhu G, Li Y, Liu C, Yang R, Tang Z, Li J, Huang W, Chen L, Zheng X, He Y, Tan J. The invasion of tobacco mosaic virus RNA induces endoplasmic reticulum stress-related autophagy in HeLa cells. Biosci Rep. 2012 Apr 1;32(2):171-86.

  5) Wu K, Chen L, Peng G, Zhou W, Pennell CA, Mansky LM, Geraghty RJ, Li F. A virus-binding hot spot on human angiotensin-converting enzyme 2 is critical for binding of two different coronaviruses. J Virol. 2011 Jun;85(11):5331-7.

  6) Yuling H, Ruijing X, Li L, Xiang J, Rui Z, Yujuan W, Lijun Z, Chunxian D, Xinti T, Wei X, Lang C, Yanping J, Tao X, Mengjun W, Jie X, Youxin J, Jinquan T. EBV-induced human CD8+ NKT cells suppress tumorigenesis by EBV-associated malignancies. Cancer Res. 2009 Oct 15;69(20):7935-44.