近日，湖北省教育厅评选出了“2014年湖北省教学名师”，我院章晓联教授入选。
章晓联，二级教授，珞珈学者，国家杰出青年基金获得者，新世纪“百千万人才工程”入选者，国家双语教学示范课程负责人，曾获宝钢优秀教师奖、中国青年女科学家提名奖、全国女职工建功立业标兵、湖北省首届医学领军人才荣誉称号。章晓联多年来一直从事医学免疫学课程的主讲教师和双语教学工作，主编的《医学免疫学》、《免疫学双语实验技术指导》教材被全国数十所高等院校采用，发行量达万册以上。章晓联积极发扬教育教学创新精神，结合国内外专业特点优化教学体系，形成了具有一定特色的教学模式，获得了丰富的教研成果，为完善PI团队制，改进教研梯队做出了重要的贡献。章晓联利用一切机会加强对青年教师的培养，不仅就课堂问题进行讨论，还将自己的课件和软件交给青年教师作为“靶点”讨论，已培养了多名优秀的青年教师。
章晓联教授英文简介：
|
Xiao-Lian Zhang |
||
|
|
/Position |
Chair of Immunology Department, Director of Hubei Province Key Laboratory of Allergy and Immunology, Professor of State Key Laboratory of Virology Wuhan University School of Medicine, Wuhan 430071, China |
|
Research Field |
Infection and Immunology Glycoimmunity |
|
|
keywords of my ongoing research work |
Hepatitis C Virus Mycobacterium Tuberculosis Lectin, pathogen surface glycans Immune escape Anti-infection immunity |
|
Research Grants and Funding
National Outstanding Youth Foundation of China, Principle Investigator.
National Grand Program on Key Infectious Disease, Principle Investigator.
National 973 Program of China. Principle Investigator.
Prof. Xiao-LianZhang has published more than 100 professional research papers. She has applied for 42 patents and 25 patents were authorized.
Selected Publications in recent five years (*: corresponding author)
(1) Qian XJ#, Zhang XL#, Zhao P, Jin YS, Chen HS, Xu QQ, Ren H, Zhu SY, Tang HL, Zhu YZ, Qi ZT. A Schisandra-Derived Compound Schizandronic Acid Inhibits Entry of Pan-HCV Genotypes into Human Hepatocytes. Sci Rep. 2016 Jun 2; 6:27268. doi: 10.1038/srep27268.
(2) Sun X, Pan Q, Yuan C, Wang Q, Tang XL, Ding K, Zhou X, Zhang XL*. A Single ssDNA Aptamer Binding to Mannose-Capped Lipoarabinomannan of Bacillus Calmette-Guérin Enhances Immunoprotective Effect against Tuberculosis. J Am Chem Soc. 2016; 138(36):11680-9.
(3) Luo F, Chen T, Liu J, Shen X, Zhao Y, Yang R, Zhang XL*. Ficolin-2 binds to HIV-1 gp120 and blocks viral infection. Virol Sin. 2016 Oct; 31(5):406-414.
(4) Wang SR, Min YQ, Wang JQ, Liu CX, Fu BS, Wu F, Wu LY, Qiao ZX, Song YY, Xu GH, Wu ZG, Huang G, Peng NF, Huang R, Mao WX, Peng S, Chen YQ, Zhu Y, Tian T, Zhang XL*, Zhou X*. A highly conserved G-rich consensus sequence in Hepatitis C virus core gene represents a new anti-Hepatitis C target, Science Advances, 2016. 2(4): e1501535.
(5) Tang XL, Wu SM, Xie Y, Song N, Guan Q, Yuan C, Zhou X, Zhang XL*. Generation and application of ssDNA aptamers against glycolipid antigen ManLAM of Mycobacterium tuberculosis for TB diagnosis. J Infect, 2016. 72(5):573-586.
(6) Luo FL, Sun XM, Qu Z, Zhang XL*. Salmonella typhimurium-induced M1 macrophage polarization is dependent on the bacterial O antigen. World J Microbiol Biotechnol, 2016, 32(2):22.
(7) Ren Y, Min YQ, Liu M, Chi L, Zhao P, Zhang XL*. N-glycosylation-mutated HCV envelope glycoprotein complex enhances antigen-presenting activity and cellular and neutralizing antibody responses. Biochim Biophys Acta, 2016 Aug 14. 1860(8): 1764-1775. doi: 10.1016/j.bbagen.2015.08.007.
(8) Luo W, Qu ZL, Xie Y, Xiang J, Zhang XL*. Identification of a novel immunodominant antigen Rv2645 from RD13 with potential as a cell-mediated immunity-based TB diagnostic agent. J Infect, 2015. 71(5):534-543. doi: 10.1016/j.jinf.2015.07.011.
(9) Chen T, Hu Y, Ding Q, Yu J, Wang F, Luo F, Zhang XL*. Serum ficolin-2 concentrations are significantly changed in patients with hepatitis B virus infection and liver diseases. Virol Sin, 2015 Jun;30(4):249-60.
(10) Pan Q, Li Q, Liu S, Ning N, Zhang XL, Xu Y, Chang AE, Wicha MS. Targeting Cancer Stem Cells Using Immunologic Approaches. Stem Cells. 2015, 33(7):2085-2092.
(11) Wang T, Hong T, Huang Y, Su H, Wu F, Chen Y, Wei L, Huang W, Hua X, Xia Y, Xu J, Gan J, Yuan B, Feng Y, Zhang XL, Yang CG, Zhou X. Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein. J Am Chem Soc. 2015, 137(43):13736-13739.
(12) Ding F, Guo S, Xie M, Luo W, Yuan C, Huang W, Zhou Y, Zhang XL*, and Zhou X*. Diagnostic applications of gastric carcinoma cell aptamers in vitro and in vivo. Talanta, 2015, 134:30-36.
(13) Zhao Y, Ren Y, Zhang X, Zhao P, Tao W, Zhong J, Li Q, Zhang XL*. (2014). Ficolin-2 inhibits Hepatitis C Virus infection, whereas apolipoprotein E3 mediates viral immune escape. J Immunol. 193(2):783-96.
(14) Pan Q, Wang Q, Sun X, Xia X, Wu S, Luo F, Zhang XL*. (2014). Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeys. Mol Ther. 22(5):940-51.
(15) Tang XL, Zhou YX, Wu SM, Pan Q, Xia B, Zhang XL*. （2014）CFP10 and ESAT6 aptamers as effective Mycobacterial antigen diagnostic reagents. J Infect. 2014 Jun 23. pii: S0163-4453(14)00167-4. doi: 10.1016/j.jinf.2014.05.015.
(16) Luo F, Sun X, Wang Y, Wang Q, Wu Y, Pan Q, Fang C, Zhang XL*. (2013). Ficolin-2 defends against virulent Mycobacteria Tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. PloS One, 8 (9): e73859.
(16) Pan Q, Chen H, Wang F , Jeza VT , Hou W, Zhao Y, Xiang T, Zhu Y, Endo Y, Fujita T, Zhang XL* (2012). L-ficolin binds to glycoproteins HA and NA and inhibits influenza A virus infection both in vitro and in vivo. J Innate Immun 4:312-24.
(17) Chen HD, Zhou X, Yu G, Zhao YL, Ren Y, Zhou YD, Li Q, Zhang XL* (2012). Knockdown of core 1 beta 1, 3-galactosyltransferase prolongs skin allograft survival with induction of galectin-1 secretion and suppression of CD8+T cells. J Clin Immunol 32:820-836.
Contact Information
Tel.: 86-27-68759986 (O);
E-mail: zhangxiaolian@whu.edu.cn; zhangXL65@sina.com