彭碧文教授团队
2019-06-07 20:40:45
彭碧文，博士，生理学教授，博士生导师。
武汉大学基础医学院生理学系副主任，中国生理学会理事及湖北省暨武汉市生理学会副理事长。
主要研究方向为神经系统离子通道病的神经-免疫机制研究。先后主持国家级课题4项，省、市部级课题多项，同时参与国家自然科学基金项目及美国NIH资助项目的研究。共发表相关论文60余篇,其中SCI论文40余篇，并参与3部专著的编写。研究成果获福建省科学技术三等奖一项。
在研项目：
1. 国家自然科学基金面上项目：TRPV1通过小胶质细胞激活介导发作性疾病的机制研究 (No. 81571481)，2016-2019，57万，主持
代表性论文：
1. Yang XL#, Wang X#, Shao L, Jiang GT, Min JW, Mei XY, He XH, Liu WH, Huang WX*, Peng BW*. TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI). J Neuroinflammation. 2019; 16(1):114.
2. Yang XL, Wang X, Peng BW*. NFAT5 has a job in the brain. Developmental Neuroscience. 2018; 40(4):289-300.
3. Luo WD, Min JW, Huang WX, Wang X, Peng YY, Han S, Yin J, Liu WH, He XH, Peng BW*. Vitexin reduces epilepsy after hypoxic ischemia in the neonatal brain via inhibition of NKCC1. J Neuroinflammation. 2018; 15(1):186.
4. Kong WL, Peng YY, Peng BW*. Modulation of neuroinflammation: Role and therapeutic potential of TRPV1 in the neuro-immune axis. Brain Behavior and Immunity. 2017; 64:354-366.
5. Min JW, Kong WL, Han S, Bsoul N, Liu WH, He XH, Sanchez RM, Peng BW*. Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain. Oncotarget. 2017; 8(15):25513-25524.
6. Hu JJ, Yang XL, Luo WD, Han S, Yin J, Liu WH, He XH, Peng BW*. Bumetanide reduce the seizure susceptibility induced by pentylenetetrazol via inhibition of aberrant hippocampal neurogenesis in neonatal rats after hypoxia-ischemia. Brain Research Bulletin. 2017; 130C:188-199.
7. He M, Min JW, Kong WL, He XH, Li JX, Peng BW*. A review on the pharmacological effects of vitexin and isovitexin. Fitoterapia. 2016; 115:74-85. (3区，SCI=2.4, 通讯作者)
8. Min JW, Hu JJ, He M, Sanchez RM, Huang WX, Liu YQ, Bsoul N, Han S, Yin J, Liu WH, He XH*, Peng BW*. Vitexin reduces hypoxia-ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model. Neuropharmacology. 2015; 99:38-50.
9. Huang WX, Yu F, Sanchez RM, Liu YQ, Min JW, Hu JJ, Bsoul N, Han S, Yin J, Liu WH, He XH*, Peng BW*. TRPV1 promotes the occurrence of repetitive febrile seizures by increasing the secretion of pro-inflammatory cytokines in the immature brain. Brain Behavior and Immunity. 2015; 48:68-77.
10. Liu YQ, Huang WX, Sanchez RM, Min JW, Hu JJ, He XH, Peng BW*. Regulation of Kv4.2 A-Type Potassium Channels in HEK-293 Cells by Hypoxia. Frontiers in Cellular Neuroscience. 2014; 8:329.