张秋萍教授团队

2019-06-07 20:25:02

张秋萍，博士，免疫学系教授，博士生导师。

武汉大学基础医学院免疫学系副主任、主要学术兼职：中国病理生理学会血液免疫专家组成员、中国免疫学会女科学家工作委员会首届委员、湖北省医学生物免疫学会基础免疫专业委员会副主任委员。

主要研究方向为肿瘤免疫。主持国家自然科学基金面上项目5项。首次发现：CCR9在T-ALL中高表达介导白血病的浸润和耐药，并利用基因工程技术制备了CCL25-PE38免疫毒素，该物质可以特异性杀伤CCR9⁺的肿瘤细胞，是治疗CCR9⁺肿瘤的潜在候选药物。发表多篇SCI论文。

在研项目：

1. 国家自然基金项目：LncRNA TCONS_00024295调控CCR9在T-ALL转移中的作用及机制研究，2017-2021，55万，主持

荣誉与获奖：

1. 科研成果“白血病和多发性骨髓瘤的研究”，2013获湖北省自然科学三等奖，第一完成人

2. 科研成果“ERM蛋白参与CCR9介导急性T淋巴细胞白血病耐药机制的研究”，获湖北省优秀博士生论文

代表性论文：

1. Wu Y^#, Pan S^#, Leng J^#, Xie T, Jamal M, Yin Q, Li J, He C, Dong X, Shao L*, Q Zhang*: The prognostic value of matrix metalloproteinase-7 and matrix metalloproteinase-15 in acute myeloid leukemia. J Cell Biochem. 2019; 120(6):10613-10624.

2. Tu Z^#, Xiong J^#, Xiao R^#, Shao L, Yang X, Zhou L, Yuan W, Wang M, Yin Q, Wu Y, Pan S, Leng J, Jiang D, He C, Zhang Q*: Loss of miR-146b-5p promotes T cell acute lymphoblastic leukemia migration and invasion via the IL-17A pathway. J Cell Biochem. 2019; 120(4):5936-5948.

3. Xie S^#, Tu Z^#, Xiong J, Kang G, Zhao L, Hu W, Tan H, Tembo KM, Ding Q, Deng X, Huang J, Zhang Q*: CXCR4 promotes cisplatin-resistance of non-small cell lung cancer in a CYP1B1-dependent manner. Oncol Rep. 2017; 37(2):921-928.

4. Z Tu^#, S Xie^#, M Xiong, Y Liu, X Yang, K M. Tembo, J Huang, W Hu, X Huang, S Pan, P Liu, E Altaf, G Kang, J Xiong*, Zhang Q*: CXCR4 is involved in CD133-induced EMT in non-small cell lung cancer. Int J Oncol. 2017; 50(2):505-514.

5. Deng X^#, Tu Z^#, Xiong M^#, Tembo K, Zhou L, Liu P, Pan S, Xiong J, Yang X, Leng J, Zhang Q, Xiao R*, Zhang Q*: Wnt5a and CCL25 promote adult T-cell acute lymphoblastic leukemia cell migration, invasion and metastasis. Oncotarget 2017, 8(24):39033-39047.

6. Huang X^#, Xiao R^#, Pan S, Yang X, Yuan W, Tu Z, Xu M, Zhu Y, Yin Q, Wu Y, Hu W, Shao L, Xiong J, Zhang Q*: Uncovering the roles of long non-coding RNAs in cancer stem cells. J Hematol Oncol. 2017; 10(1):62.

7. Altaf E^#, Huang X^#, Xiong J, Yang X, Deng X, Xiong M, Zhou L, Pan S, Yuan W, Li X, Hao L, Tembo KM, Xiao R, Zhang Q*: NHE1 has a notable role in metastasis and drug resistance of T-cell acute lymphoblastic leukemia. Oncol Lett. 2017; 14(4):4256-4262.

8. Li X^#, Xiao R, Tembo KM, Hao L, Xiong M, Pan S, Yang X, Yuan W, Xiong J*, Zhang Q*: PEG10 promotes human breast cancer cell proliferation, migration and invasion. Int J Oncol. 2016; 48(5):1933-1942.

9. Tu Z^#, Xiao R ^#, Xiong J, Tembo KM, Deng X, Xiong M, Liu P, Wang M, Zhang Q*: CCR9 in cancer: oncogenic role and therapeutic targeting. J Hematol Oncol. 2016; 9:10.

10. Huang X^#, Xiong M, Jin Y, Deng C, Xu H, An C, Hao L, Yang X, Deng X, Tu Z, Li X, Xiao R, Zhang Q*: Evidence that high-migration drug-surviving MOLT4 leukemia cells exhibit cancer stem cell-like properties. Int J Oncol. 2016; 49(1):343-351.