陈效教授团队
2019-06-07 19:47:07
陈效，博士，博士生导师。
武汉大学基础医学院药理学系教授。兼任武汉药理学会秘书长长。研究领域为纳米材料与生物机体的相互作用及其细胞分子机制；将纳米材料/药物用于人类疾病的诊断与治疗。当前方向纳米药物递送系统调控肿瘤免疫微环境以及用于肿瘤的免疫治疗。主持国家、省、市科研项目多项。发表论著二十余篇。
在研项目：
1. 国家自然科学基金面上项目：利用纳米药物靶向干预炎性单核细胞和肿瘤相关巨噬细胞治疗脑胶质瘤 (No. 81671818)，2017-2020
2. 湖北省卫健委科研计划重点支撑项目：基于树突状细胞递送纳米药物调控肿瘤免疫微环境的脑胶质瘤免疫治疗策略及其机制研究 (No. WJ2019Z010)，2019-2020
3. 武汉市科技计划项目：利用纳米药物靶向调控免疫微环境治疗脑胶质瘤的研究 (No. 2017060201010148)，2017-2019
4. 武汉大学医学腾飞计划重大科研项目：发育编程与代谢性疾病，2019-2021，参与
代表性论文：
1. Li TF, Xu YH, Li K, Wang C, Liu X, Yue Y, Chen Z, Yuan SJ, Wen Y, Zhang Q, Han M, Komatsu N, Zhao L*, Chen X*. Doxorubicin-polyglycerol-nanodiamond composites stimulate glioblastoma cell immunogenicity through activation of autophagy. Acta Biomater. 2019; 86:381-394.
2. Chen Z, Wang C, Li TF, Li K, Yue Y, Liu X, Xu HZ, Wen Y, Zhang Q, Han M, Komatsu N, Xu YH, L Zhao*, Chen X*. Doxorubicin conjugated with nanodiamonds and in free form commit glioblastoma cells to heterodromous fates. Nanomedicine (Lond). 2019; 14(3):335-351.
3. Li TF, Li K, Zhang Q, Wang C, Yue Y, Chen Z, Yuan SJ, Liu X, Wen Y, Han M, Komatsu N, Xu YH, Zhao L*, Chen X*. Dendritic cell-mediated delivery of doxorubicin-polyglycerol-nanodiamond composites elicits enhanced anti-cancer immune response in glioblastoma. Biomaterials. 2018; 181:35-52.
4. Li TF, Li K, Wang C, Liu X, Wen Y, Xu YH, Zhang Q, Zhao QY, Shao M, Li YZ, Han M, Komatsu N, Zhao L*, Chen X*. Harnessing the cross-talk between tumor cells and tumor-associated macrophages with a nano-drug for modulation of glioblastoma immune microenvironment. J Control Release. 2017; 268:128-146.
5. Wang C, Li K, Li T, Chen Z, Wen Y, Liu X, Jia X, Zhang Y, Xu Y, Han M, Komatsu N, Zhao L*, Chen X*. Monocyte-mediated chemotherapy drug delivery in glioblastoma. Nanomedicine (Lond). 2018; 13 (2):157-178.
6. Wang ZJ, Xu YH, Meng XN, Watari F, Liu HD*, Chen X*. Suppression of c-Myc is involved in multi-walled carbon nanotubes' down-regulation of ATP-binding cassette transporters in human colon adenocarcinoma cells. Toxicol Appl Pharm. 2015; 282(1):42-51.
7. Zhao L, Xu Y, Qin H, Abe S, Akasaka T, Chano T, Watari F, Kimura T, Komatsu N*, Chen X*. Platinum on Nanodiamond: A Promising Prodrug Conjugated with Stealth Polyglycerol, Targeting peptide, and Acid-Responsive Antitumor Drug. Adv Funct Mater. 2014; 24(34):5348–5357.
8. Zhao L, Xu Y, Abe S, Akasaka T, Watari F, Kimura T, Komatsu N, Chen X*. Polyglycerol-coated nanodiamond as a macrophage-evading platform for selective drug delivery in cancer cells. Biomaterials. 2014; 35(20):5393–5406.