汪琳教授团队
2019-05-10 17:22:48
汪琳，博士，组织学与胚胎学专业教授，博士生导师。
武汉大学基础医学院组织学与胚胎学教研室主任，兼任湖北省解剖学会副理事长、国家自然科学基金一审专家、国家留学基金评审专家、中国博士后基金评审专家、北京市自然科学基金评审专家、中国组织化学与细胞化学杂志编委、武汉大学学报医学版编委等。
主要研究方向为：1)生殖生物学，关注胚胎植入的分子机制以及不良宫内环境对胚胎发育的影响；2)围生期新生儿感染性疾病，主要是利用血脑屏障的细胞及动物模型，研究新生儿脑膜炎大肠杆菌等病原菌穿过血脑屏障的分子机制。主持多项研究课题，包括国家自然科学基金面上项目、教育部科学技术研究重点项目、湖北省卫生计生西医类重点项目、湖北省自然科学基金项目等。发表第一或通讯作者论文20余篇，其中SCI收录论文15篇。
代表性论文：
1. Liu R, Wu C, Li L, Chi F, Zhang T, Xu Y, Ji L, Chen Z, Hu H, Zhang X, Huang S, Wang L*. CD48 and α7 nAChR Synergistically Regulate FimH-mediated E. coli K1 Penetration and Neutrophil Transmigration Across Human Brain Microvascular Endothelial Cells. J Infect Dis. 2019; 219(3):470-479.
2. Ji L, Chen Z, Xu Y, Xiong G, Liu R, Wu C, Hu H, Wang L*. Systematic Characterization of Autophagy in Gestational Diabetes Mellitus. Endocrinology. 2017; 158(8):2522-2532.
3. Zhang XL#, Wang L#, Xiong L, Huang FH, Xue H. Timosaponin B-III exhibits antidepressive activity in a mouse model of postpartum depression by the regulation of inflammatory cytokines, BNDF signaling and synaptic plasticity. Exp Ther Med.2017; 14:3856-3861.
4. Zhang X#, Wang L#, Huang F, Li J, Xiong L, Xue H, Zhang Y. Evaluation of the promoter region polymorphism (5‑HTTLPR) in the serotonin transporter gene in females with postpartum depression. Exp Ther Med. 2015; 9:245-249.
5. Zhang X, Wang L, Huang F, Li J, Xiong L, Xue H, Zhang Y. Gene-environment interaction in postpartum depression: a Chinese clinical study. J Affect Disord. 2014; 165:208-12.
6. Huang SH#*, Wang L#, Chi F#, Wu CH, Cao H, Zhang A, Jong A. Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood–brain barrier disorders caused by microbial and non-microbial factors. PLoS One. 2013; 8(4):e62164.
7. He L, Chi F, Bo T, Wang L, Wu CH, Jong A, Huang SH*. p54nrb, a PSF protein partner, contributes to meningitic Escherichia coli K1-mediated pathogenicities. Open Journal of Applied Sciences. 2012.
8. Chi F#, Wang L#, Zheng X, Wu CH, Jong A, Sheard MA, Shi W, Huang SH*. Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor. PLOS ONE. 2011; 6(9):e25016.
9. Chi F#, Wang L#, Zheng X, Jong A, Huang SH*. Recruitment of α7 nicotinic acetylcholine receptor to caveolin-1-enriched lipid rafts is required for nicotine-enhanced Escherichia coli K1 entry into brain endothelial cells. Future Microbiology. 2011; 6:953-66.
10. Che X#, Feng Chi#, Wang L#, Jong TD, Wu CH, Wang X, Huang SH*. Involvement of IbeA in meningitic Escherichia coli K1-induced Polymorphonuclear leukocyte transmigration across brain endothelial cells. Brain Pathology. 2011; 21(4):389-404.