洪学传教授团队
2019-05-10 17:22:09
洪学传,博士,珞珈特聘教授,博士生导师。
现兼任中国生物物理学会分子影像学专业委员会委员,全国卫生产业企业管理协会精准医疗分会理事,中国生物化学与分子生物学会蛋白质组学专业理事,中国药理学学会分析药理学专业委员会委员,湖北省科技进步促进会常务理事,湖北省保健食品和化妆品评审员。《中国药物化学杂志》、《Wuhan University Journal of Natural Sciences》、《Chinese Chemical Letters》、《Journal of Biochemistry and Molecular Biology Research》和《医药导报》编委。
2003年至今已在国内、国际核心化学期刊包括Nat. Mater., Nat. Commun.、J. Am. Chem. Soc.、Angew. Chem、Int. Ed.、Chem. Sci.、J. Med. Chem.上发表相关论文。
在研项目:
1. 国家自然科学基金面上项目:动脉粥样硬化斑块的NIRF-II/MRI双模态分子成像研究 (No. 81773674),2018-2021,58万
2. 深圳市知识创新计划基础研究项目:近红外II区小分子探针的构建及肿瘤手术导航研究 (No. 2017CFA024),2017-2020,50万
3. 湖北省自然科学基金创新团队项目:乳腺癌靶点小分子精准调控及诊疗一体化研究 (No. 81773674), 2017-2020,20万
4. 国家自然科学基金面上项目:uPAR受体靶向的新型双模态分子探针的研制及显像研究 (No. 81573383),2016-2019,60万
荣誉与获奖:
1. 2014年获武汉市第三批“黄鹤英才”人才计划
2. 2014年获美国化学会组织颁发的第九届世界华人药学会最佳报告奖
3. 2015年获武汉大学医学部医学突出贡献奖
4. 2016年武汉大学珞珈学者特聘教授,武汉大学医学部医学突出贡献奖,武汉大学朱裕璧医学奖
代表性论文:
1. Ding B #, Xiao Y#, Zhou H#, Zhang X, Qu C, Xu F, Deng Z, Cheng Z, Hong X*. Polymethine thiopyrylium fluorophores with absorption beyond 1000 nm for biological imaging in the second near-infrared sub-window. J. Med. Chem. 2019; 62:2049−2059.
2. Lin J#, Zeng X#, Xiao Y#, Tang L, Nong J, Liu Y, Zhou H, Ding B, Xu F, Tong H, Deng Z, Hong X*. Novel near-Infrared II aggregation-induced emission dots for in vivo bioimaging. Chem. Sci. 2019; 10:1219-1126.
3. Sun Y#, Zeng X#, Xiao Y#, Liu C, Zhu H, Zhou H, Chen Z, Xu F, Wang J, Zhu M, Wu J, Deng Z, Cheng Z*, Hong X*. Dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery. Chem. Sci. 2018; 9:2092–2097.
4. Ding M#, Wang H#, Qu C#, Xu F#, Zhu Y, Lv G, Lu Y, Zhou Q, Zhou H, Zeng X, Zhang J, Yan C, Lin J, Luo HR, Deng Z, Xiao Y, Tian J, Zhu MX, Hong X*, Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer. Cancer Lett. 2018; 432:47–55.
5. Qu C#, Ding M#, Zhu Y#, Lu Y, Du J, Miller M, Tian J, Zhu J, Xu J, Wen M, Er-Bu A, Wang J, Xiao Y, Wu M, McManus OB, Li M, Wu J, Luo HR, Cao Z, Shen B, Wang H*, Zhu MX*, Hong X*. Pyrazolopyrimidines as potent stimulators for transient receptor potential canonical 3/6/7 channels. J. Med. Chem. 2017; 60(11):4680−4692.
6. Antaris AL#, Chen H#, Diao S, Ma Z, Zhang Z, Zhu S, Wang J, Lozano AX, Fan Q, Chew L, Zhu M, Cheng K, Hong X*, Dai H*, Cheng Z*, A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging. Nat. Commun. 2017; 8:15269.
7. Sun Y#, Ding M#, Zeng X#, Xiao Y#, Wu H, Zhou H, Ding B, Qu C, Hou W, Er-Bu A, Zhang Y, Cheng Z, Hong X*. Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery. Chem. Sci. 2017; 8:3489-3493.
8. Sun Y#, Qu C#, Chen H, He M, Tang C, Shou K, Hong S, Yang M, Jiang Y, Ding B, Xiao Y, Xing L, Hong X*, Cheng Z*. Novel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer, Chem. Sci. 2016; 7:6203-6207.
9. Sun Y, Hong S, Ma X, Cheng K, Wang J, Zhang Z, Yang M, Jiang Y, Hong X*, Cheng Z*. Recyclable Cu(I)/Melanin dots for cycloadditions, bioconjugation and cell labeling. Chem. Sci. 2016; 7:5888-5892.
10. Antaris AL#, Chen H#, Cheng K, Sun Y, Hong G, Qu C, Diao S, Deng Z, Hu X, Zhang B, Zhang X, Yaghi OK, Alamparambil ZR, Hong X*, Cheng Z*, Dai H*. A small molecule dye for NIR II imaging. Nat. Mater. 2016; 15(2):235–242.
11. Sun Y, Ma X, Cheng K, Wu B, Duan J, Chen H, Bu L, Zhang R, Hu X, Deng Z, Xing L, Hong X*, Cheng Z*. Strained Cyclooctyne as a Molecular Platform for Construction of Multimodal Imaging Probes. Angew. Chem. Int. Ed. 2015; 54(20):5981-5984.