1、职称职务：教授、博士生导师、病理生理学教研室主任
2、学科专业：病理生理学
3、研究方向： 代谢综合征
4、联系电话： 027-68759846
5、Email： chwang0525@whu.edu.cn
6、学习经历
武汉大学医学院内科学博士
7、主要工作经历与任职
2008年10月-至今：病理生理学教研室副教授、教授、副主任、主任
2014年1月-2015年8月，美国University of South Dakota Sanford School of Medicine， Research Assistant Professor
2010年10月-2011年9月，美国University of South Dakota Sanford School of Medicine，访问研究科学家（Visiting Research Scientist）
2004年7月-2008年9月，美国University of Texas Health Science Center at San Antonio药理学系，研究科学家（Research Scientist）
2003年3月-2003年8月，法国Henri Poincare Université, Nancy 1大学药学院，高级访问学者
2002年5月-2004年6月：基础医学院生理学教研室副教授、副主任（牵头）
8、目前主要科学研究领域和兴趣
①阐明糖尿病发生、发展的分子机制， 尤其是胰岛素信号转导、脂联素信号转导的分子机制；②探讨蛋白质质量控制在重大疾病，如糖尿病、心血管等疾病发生中的作用；③探讨糖尿病与肿瘤的相互关系，及其潜在的机制。拟通过细胞和动物复制疾病模型，采用转基因或基因敲除鼠、分子生物学、形态学等多种手段探讨糖尿病的发生机制，及其与心血管疾病和肿瘤等疾病的相互关系。
目前我们的研究兴趣集中在肥胖、糖尿病及其相关疾病,包括癌症的基本机制。我们正在研究蛋白质质量控制监管作用，特别是自噬和蛋白酶体诱导的蛋白降解在与肥胖相关的癌症发展中和脂肪细胞中的功能。我们也研究在癌症细胞和脂肪细胞中自噬和蛋白酶体之间的功能联系。
9、教学情况
从事病理生理学理论和实验教学
10、近5年代表性论文
1. Yao X, Liu H, Zhang X, Zhang L, Li X, Wang C, Sun S. Cell Surface GRP78 Accelerated Breast Cancer Cell Proliferation and Migration by Activating STAT3. PLoS One. 2015 May 14;10(5):e0125634.
2. Zhang Y, Ye M, Chen LJ, Li M, Tang Z, Wang C. Role of the ubiquitin-proteasome system and autophagy in regulation of insulin sensitivity in serum-starved 3T3-L1 adipocytes. Endocrine Journal. 2015;62(8):673-686.
3. Zhang Y, Li M, Tang Z, Wang C. Wogonin suppresses osteopontin expression in adipocytes by activating PPARα. Acta Pharmacologica Sinica. 2015; 36(8): 987–997.
4. Wang C, Wang X. The interplay between autophagy and the ubiquitin-proteasome system in cardiac proteotoxicity. Biochim Biophys Acta. 2015 Feb;1852(2):188-94.
5. Tian Z, Wang C, Hu C, Tian Y, Liu J, Wang X. Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes. PLoS One. 2014 Jun 24;9(6):e100715.
6. Ryu J, Galan AK, Xin X, Dong F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo S, Musi N, DeFronzo RA, Deng C, White MF, Liu F, Dong LQ. APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor. Cell Rep. 2014 May 22;7(4):1227-38.
7. Liu YM, Wang X, Nawaz A, Kong ZH, Hong Y, Wang CH, Zhang JJ. Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway. Acta Pharmacol Sin. 2011Dec;32(12):1475-82.
8. Deepa SS, Zhou L, Ryu J, Wang C, Mao X, Li C, Zhang N, Musi N, DeFronzo RA, Liu F, Dong LQ. APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway. Mol Endocrinol. 2011Oct;25(10):1773-85.
9. Sun S, Liu Y, Lu J, Omar A, Sun S, Bi Y, Wang C. The inhibitory effects of PKCθ on adiponectin expression is mediated by ERK in 3T3-L1 adipocytes. J Endocrinol Invest. 2011 Jan;34(1):8-15.
10. Sun S, Wang X, Wang C, Nawaz A, Wei W, Li J, Wang L, Yu DH. Arctigenin suppresses unfolded protein response and sensitizes glucose deprivation-mediated cytotoxicity of cancer cells. Planta Med. 2011 Jan;77(2):141-5.
11. Wang X, Yu W, Nawaz A, Guan F, Sun S, Wang C. Palmitate induced insulin resistance by PKCtheta-dependent activation of mTOR/S6K pathway in C2C12 myotubes. Exp Clin Endocrinol Diabetes. 2010 Oct;118(9):657-61.
12. Wang C, Xin X, Xiang R, Ramos FJ, Liu M, Lee HJ, Chen H, Mao X, Kikani CK, Liu F, Dong LQ. Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells. J Biol Chem. 2009 Nov 13;284(46):31608-15.
13. Wang C, Liu M, Riojas RA, Xin X, Gao Z, Zeng R, Wu J, Dong LQ, Liu F. Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance. J Biol Chem. 2009 Jan 23;284(4):2038-44.
14. Wang C, Mao X, Wang L, Liu M, Wetzel MD, Guan KL, Dong LQ, Liu F. Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1. J Biol Chem. 2007 Mar 16;282(11):7991-6.
15. Riojas RA, Kikani CK, Wang C, Mao X, Zhou L, Langlais PR, Hu D, Roberts JL, Dong LQ, Liu F. Fine tuning PDK1 activity by phosphorylation at Ser163. J Biol Chem. 2006 Aug 4;281(31):21588-93.